Biomarkers

Expanded USPSTF BRCA1/2 testing recommendations may not go far enough

Recently updated guidelines from the U.S. Preventive Services Task Force (USPSTF) have substantially expanded the pool of individuals for whom breast cancer susceptibility gene (BRCA)-related cancer risk assessment is warranted. But does the update go far enough?
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BRCA mutations confer high risk of CNS metastases

Patients with newly recurrent breast cancer who carry a germline BRCA1 or BRCA2 mutation are about twice as likely as noncarriers to have central nervous system involvement, finds a single-center retrospective cohort study. And carrying a BRCA2 mutation independently predicts such involvement and death from the disease.
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